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Alloferon is a novel immunomodulatory peptide
consisting of 13 amino acids and has a molecular weight of 1,265
daltons. Alloferon was originally isolated from the blood of
an experimentally infected insect, the blow fly Calliphora
vicina, but EntoPharm succeeded in synthesize it. Most of
the preclinical trials and all of the clinical trials were conducted
with synthetic version of Alloferon.
Alloferon shows no sequence similarity to any known human or
animal cytokine, but does show structural similarities to the
hemagglutinin sector of the influenza virus, responsible for
adhesion on the membrane of the host cell. |
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In addition to its current injectable form as
used in clinical trials, Alloferon is being developed for intranasal
administration. EntoPharm is also examining the possibilities
of developing diverse formulation of Alloferon for oral or transdermal
administration with its strategic partner, Pacific Pharm. |
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Alloferon is now being synthesized
at the peptide lab of Alloferon Co. in Russia. It is currently
produced in lyophilized powder form and packaged in ampoules
but will be available in vials for the Korean market.
Alloferon is usually dissolved in 1.0 milligram of saline
by clinicians for injection purposes. |
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